Dental caries remain a public health problem for many developing countries and for underprivileged populations in developed countries.This paper outlines the historical development of public health approaches to the use of fluoride and comments on their effectiveness.Early research and development was concerned with waterborne fluorides, both natur
To identify genetic changes underlying dog domestication and reconstruct their early evolutionary history, we generated high-quality genome sequences from three gray wolves, one from each of the three putative centers of dog domestication, two basal dog lineages (Basenji and Dingo) and a golden jackal as an outgroup.Analysis of these sequences supp
Oncolytic virotherapy has shown impressive results in preclinical studies and first promising therapeutic outcomes in clinical trials as well.Since viruses are known for a long time as excellent vaccination agents, oncolytic viruses rawlings fungo are now designed as novel anticancer agents combining the aspect of lysis-dependent cytoreductive acti
The gammacoronavirus avian infectious bronchitis virus (IBV) is a highly contagious respiratory pathogen of primary economic importance to kathy chilton iris the global poultry industry.Two IBV lineages (GI-11 and GI-16) have been widely circulating for decades in South America.GI-11 is endemic to South America, and the GI-16 is globally distribute